Reading list
Thymulin bibliography
The human zinc experiment is the starting point. The binding-protein and cell-culture papers are where the story becomes especially interesting.
Human zinc study and hormone characterization
Serum thymulin in human zinc deficiency supplies the normal-plasma-zinc, reduced-thymulin-activity finding. Thymulin, a zinc-dependent hormone supplies the characterization of the hormone and its zinc dependence. Those are the starting studies for this site.
Zinc-binding proteins and mouse experiments
The alpha-2-macroglobulin study and metallothionein paper address zinc-binding partners in different settings. The oral-zinc experiment in old mice and organ-culture experiment are best considered side by side, with their different interventions in view.
Human cell preparations
The remaining papers concern marrow precursors, lymphocytes from autoimmune-disease patients and lymphocytes from severely malnourished children. All describe in vitro work. The full bibliographic entries follow.
- Serum thymulin in human zinc deficiency ↗
- Thymulin, a zinc-dependent hormone ↗
- Role of zinc and alpha2 macroglobulin on thymic endocrine activity and on peripheral immune efficiency (natural killer activity and interleukin 2) in cervical carcinoma ↗
- Are zinc-bound metallothionein isoforms (I+II and III) involved in impaired thymulin production and thymic involution during ageing? ↗
- Reversibility of the thymic involution and of age-related peripheral immune dysfunctions by zinc supplementation in old mice ↗
- Age-related thymus involution: zinc reverses in vitro the thymulin secretion defect ↗
- Induction of differentiation in human marrow T cell precursors by the synthetic serum thymic factor, FTS ↗
- In vitro lymphocyte-differentiating effects of thymulin (Zn-FTS) on lymphocyte subpopulations of severely malnourished children ↗
- Thymulin (FTS-Zn) induced in vitro modulation of T cell subsets markers on lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients ↗