# Thymulin bibliography

> The BioLink Peptides reading list — The BioLink Peptides reading list: human zinc deficiency, thymulin characterization, zinc-binding proteins, old-mouse experiments and human cell cultures.

**Reading list**

The human zinc experiment is the starting point. The binding-protein and cell-culture papers are where the story becomes especially interesting.

## Human zinc study and hormone characterization

[Serum thymulin in human zinc deficiency](https://pubmed.ncbi.nlm.nih.gov/3262625/) supplies the normal-plasma-zinc, reduced-thymulin-activity finding. [Thymulin, a zinc-dependent hormone](https://pubmed.ncbi.nlm.nih.gov/2657247/) supplies the characterization of the hormone and its zinc dependence. Those are the starting studies for this site.

## Zinc-binding proteins and mouse experiments

The [alpha-2-macroglobulin study](https://pubmed.ncbi.nlm.nih.gov/9888464/) and [metallothionein paper](https://pubmed.ncbi.nlm.nih.gov/15679929/) address zinc-binding partners in different settings. The [oral-zinc experiment in old mice](https://pubmed.ncbi.nlm.nih.gov/8582782/) and [organ-culture experiment](https://pubmed.ncbi.nlm.nih.gov/8582786/) are best considered side by side, with their different interventions in view.

## Human cell preparations

The remaining papers concern [marrow precursors](https://pubmed.ncbi.nlm.nih.gov/6969145/), [lymphocytes from autoimmune-disease patients](https://pubmed.ncbi.nlm.nih.gov/6332789/) and [lymphocytes from severely malnourished children](https://pubmed.ncbi.nlm.nih.gov/8030607/). All describe in vitro work. The full bibliographic entries follow.

## References

[1] Serum thymulin in human zinc deficiency https://pubmed.ncbi.nlm.nih.gov/3262625/
[2] Thymulin, a zinc-dependent hormone https://pubmed.ncbi.nlm.nih.gov/2657247/
[3] Role of zinc and alpha2 macroglobulin on thymic endocrine activity and on peripheral immune efficiency (natural killer activity and interleukin 2) in cervical carcinoma https://pubmed.ncbi.nlm.nih.gov/9888464/
[4] Are zinc-bound metallothionein isoforms (I+II and III) involved in impaired thymulin production and thymic involution during ageing? https://pubmed.ncbi.nlm.nih.gov/15679929/
[5] Reversibility of the thymic involution and of age-related peripheral immune dysfunctions by zinc supplementation in old mice https://pubmed.ncbi.nlm.nih.gov/8582782/
[6] Age-related thymus involution: zinc reverses in vitro the thymulin secretion defect https://pubmed.ncbi.nlm.nih.gov/8582786/
[7] Induction of differentiation in human marrow T cell precursors by the synthetic serum thymic factor, FTS https://pubmed.ncbi.nlm.nih.gov/6969145/
[8] In vitro lymphocyte-differentiating effects of thymulin (Zn-FTS) on lymphocyte subpopulations of severely malnourished children https://pubmed.ncbi.nlm.nih.gov/8030607/
[9] Thymulin (FTS-Zn) induced in vitro modulation of T cell subsets markers on lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients https://pubmed.ncbi.nlm.nih.gov/6332789/

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My curiosity about thymulin and zinc lives at BioLink Peptides, a home for published research that offers no medical advice or commercial service.